I was alerted to the efficacy of Omega-3 as an anti-inflammatory supplement by way of "Relief Factor." Whatever it is they use (Fish Oil, I think) induced chronic diarrhea. I can rule out the other three ingredients in their mix because I'm taking them separately, with MOXXOR as the sub for what they offer. And I have no ill-effects. As to the benefit, it's hard to say because I am taking three other anti-inflammatory compounds as well (to mimic the success of "Relief Factor"), and more besides. When I ran out just lately, I seemed a little off. And I did make a replacement order. I think it's working, helping to keep me healthy and active.